Fat Burning Muscle created by alteration in Steroid Receptor
by admin ~ June 27th, 2009.
According to a recently concluded study, a single protein in a combination with a related protein can play an important role in the intricate journey of the body to obesity.
This study is expected to offer the latest specific approach to treat obesity related ailments such as atherosclerosis, hyperlipidemiama, and resistance to insulin as per Dr. Ronald M. Evans, a Howard Hughes Medical Investigator at The Salk Institute’s Gene Expression Laboratory.
From News-Bio-Medicine.Org:
Dr. Ronald M. Evans, a Howard Hughes Medical Investigator at The Salk Institute’s Gene Expression Laboratory, presented two new studies (date) at Experimental Biology 2005 in the scientific sessions of the American Society for Biochemistry and Molecular Biology. The studies focus on genes for two of the nuclear hormone receptors that control broad aspects of body physiology, including serving as molecular sensors for numerous fat soluble hormones, Vitamins A and D, and dietary lipids.
The first study focuses on the gene for PPARd, a master regulator that controls the ability of cells to burn fat. When the “delta switch” is turned on in adipose tissue, local metabolism is activated resulting in increased calorie burning. Increasing PPARd activity in muscle produces the “marathon mouse,” characterized by super-ability for long distance running. Marathon mice contain altered muscle composition, which doubles its physical endurance, enabling it to run an hour longer than a normal mouse. Marathon mice contain increased levels of slow twitch (type I) muscle fiber, which confers innate resistance to weight gain, even in the absence of exercise.
Dr. Evans remarked that PPARd (Peroxisome proliferator-activated receptor delta) which acts as a master regulator for the purpose of establishing a control on the body’s ability to burn fat has the potential to suppress artery’s inflammation response to dramatically slowdown lesion progression.
The study-in-question concluded with the fact that PPARd drugs are quite effective in inhibition of atherosclerosis by limiting the inflammation level alongside enhancing physical performance.
Category: Anabolic Steroids | Tags: atherosclerosis, hyperlipidemiama, nuclear hormone receptors, obesity, peroxisome proliferator-activated receptor delta, PPARd, PPARd drugs, steroid receptor