University Network

Repeated courses of steroids (betamethasone) when administered to nursing women during preterm labor may prove effective for improving survival rate of babies.

Sanjiv Amin, M.D., assistant professor of Pediatrics at the University of Rochester Medical center and author of the study, was of the view that babies may go on ventilation when steroid treatment is avoided or delayed by nursing mothers.

The study suggested that there is no truth in the long-held belief that steroids cause brain damage to baby in wombs.

From Bio-Medicine.org:

“The consensus in recent years has been to no longer give women in preterm labor more than one course of steroids because of possible adverse effects, but it means more babies are born needing ventilation,” said Sanjiv Amin, M.D., assistant professor of Pediatrics at the University of Rochester Medical center and author of the study. “These findings may give us back a tool to help give these fragile babies a better chance of survival.”

Before concerns arose in 2000 about safety of multiple courses of steroids, many mothers in on-and-off preterm labor received several rounds before delivering. Now, when mothers go into preterm labor, obstetricians will often administer only a single course of steroids to help strengthen the baby’s lungs upon birth. But if the birth is successfully held off for more than seven days, the mother does not receive another course of medication and the baby’s lungs may not be protected.

This is regrettable, because one of the biggest challenges for babies born preterm is breathing on their own. Many develop respiratory distress syndrome because their lungs have not developed a protective film over their air sacks, called surfactant, which aids in the transfer of oxygen and decreases the work of breathing. Because of that, they may receive medications and supplemental oxygen, which can cause problems of their own.

The study noted that administration of multiple courses of betamethasone steroids do not result in any kind of infant brain damage. It was remarked by Amin that ABR (auditory brainstem evoked response) may be considered as a window into the entire brain.

Category: Uncategorized | Tags: ABR, auditory brainstem evoked response, betamethasone steroids, multiple courses of steroids, preterm labor, steroids, survival rate of babies